TODAY marks 1000 days that Cystic Fibrosis sufferers could have been accessing Orkambi.

Last month the Gazette reported that a deal for a 'life-changing' drug was close to being made available for sufferers of CF.

Pharmaceutical company Vertex were close to agreeing a deal with NHS England which would have seen Orkambi and other drugs used as treatment for the genetic condition.

Liz Brennan, a mother of three from Yate, has campaigned for the NHS and Vertex to come to an agreement.

She is the mother of Annabelle Brennan, 3, a sufferer of CF, and is looking to promote the issue again as the 1000 day mark passes.

Finley and Oscar, her two sons have written letters to Rebecca Hunt the Vice-President of the company asking pleading for a breakthrough in negotiations.

In the letters, the pair mention how the drug could help to bring happiness to their family.

"If we get the medicine then Annabelle wouldn't have to be sick and miss school," Finley said.

Oscar added in his letter: "Please can you lower the price and help my sister to get better."

Liz has spoken in the past how her children are aware of their sisters condition, but also understands the cost of developing the drug.

"I understand that Orkambi is not cheap," she said.

In the past, Liz has said: "We want to be able to plan for Annabelle's future. We don't want to have to be worried about what might happen next week."