THE brothers of a three-year-old girl from Yate have written heartfelt and moving letters to Theresa May asking if their sister can have a new drug that could potentially prolong her life.

At two months old, Annabelle Brennan was diagnosed with the life-limiting genetic disease, cystic fibrosis (CF).

The brave little girl has to take a cocktail of 20 medications a day to control the symptoms of the condition, which causes mucus to build up in the lungs and digestive system.

But new medicines have been developed which can slow the decline in lung function that CF causes.

Annabelle’s brothers, Finley, 10, and Oscar, six, who both go to the Ridge Junior School, have asked the Prime Minister to change NHS rules so that Annabelle can receive these treatments, including precision drug Orkambi, on the NHS.

The brothers’ letters join more than 1,000 messages from children across the UK that were handed in to 10 Downing Street yesterday (Wednesday, May 16), imploring Theresa May to intervene and allow access to “life-saving” treatments.

In his letter, Oscar wrote: “Dear Mrs May, I love my sister.

“I don’t want her to be sick.

“Please can she have a drug called Orkambi, which will help her lungs work more like mine.”

Finlay’s letter said: “Dear Mrs May, “I am writing a letter to say that my little sister Annabelle, who is three, has cystic fibrosis and with Orkambi she could be much healthier.

“When she runs now she struggles to breathe, but with Orkambi she could be so much better.

“I hate seeing her have so much medication. With Orkambi she won’t have to have so many drugs in her life.”

Liz Brennan, mum to Annabelle, Finley and Oscar, said: “The boys’ letters made me cry. They both love their sister so much.

“In a kid’s head, and actually in our minds too, it’s hard to understand why drugs that could make such a difference aren’t available.

“I’m trying to make the boys realise that their voices count, so it’s great for them to be able to do this.”

David Ramsden, CEO of the Cystic Fibrosis Trust, said: “Significant advances in medical science mean new precision medicines are available or in development that have the potential to transform the lives of people with CF and we urge the Prime Minister to ensure they are available for children and adults across the UK.”